Effect of short-term folic acid supplementation on insulin
sensitivity and inflammatory markers in overweight subjects
plays a pivotal role in the atherosclerotic process, and some
chemokines seem to be crucial in the pathogenesis of vascular damage.
High-serum homocysteine, recently recognized as an independent risk
factor for vascular disease might increase cytokine and chemokine
levels, thus amplifying endothelial damage; moreover, it might worse
insulin resistance, thus further contributing to enhance cardiovascular
risk. The effect of folic acid supplementation in improving in vivo
endothelial function is still debated. In this study, we investigated
the effect of folic acid supplementation on insulin sensitivity and
peripheral markers of inflammation in overweight healthy subjects.
Design: The study was performed as an
unmasked randomized placebo-controlled trial of 12 weeks duration.
healthy volunteers with normal glucose tolerance and BMI between 25 and
29 kg/m2 were enrolled.
parameters and plasma concentrations of homocysteine and of some
inflammatory molecules were measured at baseline and at the end of the
study, together with an estimation of insulin sensitivity.
receiving folic acid supplementation showed a decrement of homocysteine
and an amelioration of insulin sensitivity; this treatment was also
associated with a significant drop in the circulating concentration of
monocyte chemoattractant protein-1, interleukin-8 and C-reactive
protein, in the absence of any significant variation of BMI or fat mass.
Conclusions: In healthy overweight subjects a short-term folic acid
supplementation reduces the circulating level of some inflammatory
mediators independently of weight change, thus suggesting a potential
therapeutic role for folic acid in the protection from atherogenesis
and cardiovascular diseases.
Researchers: A Solini1,
and E Ferrannini1,2
1Department of Internal
Medicine, University of Pisa School of Medicine, Pisa, Italy
2CNR Institute of Clinical
Physiology, Pisa, Italy
Correspondence: Dr A Solini, Department of
Internal Medicine University of Pisa, Section of Internal Medicine III,
Via Roma 67, I-56100 Pisa, Italy.
Reprinted with permission by Nature Publishing Group's:
Received 27 May 2005; Revised
8 October 2005; Accepted 18 December 2005;
Published online 21 February 2006.
Reprinted by permission from Macmillan Publishers Ltd: International Journal of Obesity Original Article.
International Journal of Obesity (2006) 30, 1197–1202. doi:10.1038/sj.ijo.0803265;
published online 21 February 2006
Click here for license information.
contains pharmaceutical-grade Folic Acid with special time-released
formula to give you superior results!
SPECIAL OFFER JUST FOR READING THIS
SAVE MONEY and Get 15% OFF your
1st order of any Active 8
product by using this coupon code in the checkout process: NURK87TJ