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Clinical Studies and Published Results


 

Fast food, diuretics, alcohol, caffeine, refined and processed food, weight loss programs, influenza and the fast-paced stressful lives of everyone today creates the need for magnesium and potassium supplementationEven certain drugs can contribute to potassium deficiency. 

Magnesium is an essential macromineral, like calcium, and quickly leaves the body. Decreased levels of magnesium have been shown to be related to high blood pressure, kidney stones, heart disease (especially heart attacks due to coronary artery spasm), fatigue and PMS syndrome.

Potassium is an essential mineral, absorbed quickly in the small intestine and functions with magnesium and calcium in the regulation of neuromuscular activity.  It is essential for normal growth, to stimulate nerve impulses for muscle contraction and preserve proper alkalinity of the body fluid and regulates the water balance and acid- base balance in the blood and tissues.

Magnesium Potassium is also given as part of a treatment for autism or hyperactivity in kids along with Vitamin B6.  It may reduce broncho constriction in asthma patients by relaxing the bronchial tubes.  It fights the causes of fatigue: B6, Magnesium and Potassium Aspartates increase stamina and alleviate fatigue.

Some indications that benefit from Magnesium Potassium Aspartate:

  • Myocardial Infarctions 

  • Atherosclerosis 

  • Hypertension 

  • Angina Pectoris

  • Cardiac Arrhythmia 

  • Osteoporosis 

  • Hyperactivity 

  • Fatigue

  • Anxiety  & Depression 

  • Mood Changes 

  • Mononucleosis

  • Alcoholism 

  • Allergies 

  • Rheumatism 

  • Diabetes

  • Congestive Heart Failure 

  • Bronchial Asthma 

  • Insomnia 

  • Muscular Cramps

  • Male Genitourinary conditions

  • Prevention of Kidney Stones

  • PMS Syndrome

    In Health and Healing, Dr. Julian Whitaker refers to recent tests in which Potassium Magnesium Aspartate increased energy levels by 50% and speeded up burning of fat.

    Dr. Lawrence Resnick, endocrinologist and cardiologist at Cornell University Medical Center in New York has discovered that every individual with high blood pressure has lower than normal levels of magnesium inside their cells.  The intracellular magnesium, called free magnesium, differs from magnesium in the blood stream, which is known as circulating magnesium.  Furthermore, this low level of magnesium inside the cells occurs not only in hypertensives, but in people who are obese and in diabetics. Resnick's discovery may help explain why these three conditions are so often found in the same individual.

    Dr. Elson Haas, M.D., author of Staying Healthy With Nutrition, states supplementing magnesium has been shown to be very helpful in alleviating many symptoms related to the menstrual period.  PMS symptoms, menstrual cramps, irritability, fatigue, depression, and water retention have been lessened with magnesium, usually given along with calcium and often with Vitamin B-6.

    Dr. Haas also stressed the importance of potassium.  Potassium is a very significant body mineral, important to both cellular and electrical functions.  It is one of the main blood minerals.  Potassium is very important in cellular biochemical reactions and energy metabolism; it participates in the synthesis of protein from amino acids in the cell. Potassium also functions in carbohydrate metabolism; it is active in glycogen and glucose metabolism, converting glucose to glycogen that can be stored in the liver for future energy.  Potassium is important for normal growth and for building muscle.

    Dr. Kruse performed clinical research on 200 individuals and showed an improvement in over 85% of the individuals.  He also analyzed the results in various grouping of the individuals.

    Seven of his participants, for example, were women who had just delivered babies and were given potassium-magnesium aspartate when they left the hospital.  Each of these seven women, stated “…that they felt very good and that by comparison, with previous postpartum periods, they had much greater feeling of well being and were much better able to complete the usual chores attendant on a new infant in the family.”

    At a subsequent visit, after the trial had ended, these seven women reported “…that they felt they had been helped greatly rather unexpectedly, but that they were beginning to feel rather tired at this point.  These seven women stated that they felt more fatigued and tired than they had during the three weeks postpartum when they were taking the active substances.”

    Another subgroup detailed by Kruse was a group of 27 individuals who had just experienced a severe viral infection (influenza).  Such individuals often experience an inability to regain strength, undue desire to sleep, and a severe washed-out feeling.  Of the 27 patients in this group given the potassium-magnesium aspartate, 23 reported for follow-up.  According to Kruse, “The response was generally consistent throughout the entire group.  Their muscular weakness, their fatigue, the washed-out feeling, and the desire to sleep, seemed to subside very quickly.”

    There was also a group of 25 women who were in the early stages of menopause.  Kruse reported, “Of these 25, I found only one woman who stated she was doubtful as to whether or not the aspartates were helping her.  When given placebos as part of the investigation, “it was clear to them that there was a letdown and they would always ask what was the matter with the last batch of pills.”

    Kruse also singled out an older age group of 11 individuals aged 55-65.  Two of these individuals had fractures.  They were reported to be “interestingly responsive when given the aspartates after removal of the cast and the beginning of rehabilitation.”  Of the other nine individuals in this group, Kruse stated, “The element of fatigue, when pronounced in these people, did definitely respond to the aspartates."

    The following comments are taken from the summary section of the research paper: “During a ten month period, 200 individuals were given the magnesium and potassium salts of aspartic acid.  Some of these patients suffered only fatigue but in most, fatigue various pathologic or functional entities.”

    “Results indicate that this material in its potassium and magnesium salt forms, is physiologically effective.  It is notable that regardless of the source or type of fatigue the aspartates, in general, are helpful.  The aspartates do help the individual who is preoccupied with the fatigue itself, or who notices it to such an extent that it interferes with normal tasks in ordinary living.”

    ”In many cases the aspartates were given in conjunction with other medications, with results better than anticipated from the other materials alone.  Placebo substitution, employed in approximately half of the series, usually resulted in reversion to the condition existing prior to use of the aspartates."

    “The potassium and magnesium salts of aspartic acid, although not a panacea, afford the first truly effective physiologic treatment for chronic fatigue, whether or not it is associated with organic disease.  Proper selection of the patient is essential.  The compound should not be used indiscriminately.  The patient in need of psychiatric care only is not likely to respond.  The compound is not a substitute for other therapy required by the body (as in hypothyroidism or other medical conditions).”
     

    Daniel Shaw, MD performed one of the few studies that measured changes in the muscles and nerves in response to potassium-magnesium aspartate.  He showed differences in the electrical responses of nerves and muscles of fatigued individuals as compared to trained athletes.  He compared the electrical responses of fatigued individuals before and after administration of potassium-magnesium aspartate.
    Improvement was noted in 86% of the group and their subjective improvement was strongly correlated with changes in the electrical responsiveness in their muscles and nerves.  From the summary of their research paper: “The potassium and magnesium salts of aspartic acid have been investigated for treatment of fatigue in more than 2000 patients in the united States.  This investigation demonstrated subjective and objective evidence of relief of fatigue, whether or not organic disease was associated.  Positive and negative subjective results correlated well with objective data obtained with the electronic rheotome.”

    P.E. Formica, MD published a research paper on the use of potassium-magnesium aspartate in 100 patients (84 women and 16 men) between the ages of 18-74 years. Results showed that “A positive response was obtained in 87% of the treatment periods with the active compound.  The therapeutic response developed gradually.  The patients reported that in four to ten days (54 per cent by the 7th day) they became aware of a definite increase in energy and strength.”

    Bibliographic References for the above can be found here: references.html

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